The SOD1 G93R mutant zebrafish (referred to herein as mSOD1) ALS model, which shows motor behavioral and axonal phenotypes similar to MN disease24, was used in our drug screening platform to evaluate the toxicity and efficacy of two approved drugs‐ Ciprofloxacin and Celecoxib, individually and in combination (Fig. 1A). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.