POMC and adenoma: Comparing NFAI patients who developed ACS (ACSfu+, n = 7) with those showing no endocrine hyperfunction during follow-up (ACSfu−, n = 202), at the study entry, we found that adenoma size and prevalence of bilateral adenomas were significantly greater in ACSfu+ than ACSfu− patients, while ACTH values significantly lower in the former as compared to those in the ACSfu− group.