Knockdown of ERK5 (or MEK5) by siRNA has also shown the therapeutic potential of the ERK5 pathway in mutant BRAF-driven melanoma [31,32,33], mutant KRAS-driven pancreatic ductal adenocarcinoma (PDAC) [34], as well as prostate [35], breast [36] and bladder cancers [37]. This evidence concerns the gene MAPK7 and melanoma.