NKX3-1 and prostate neoplasm: For example, prostate tumors arise following deletion of Pten by the Nkx3.1-CreERT2 driver, which is specific for distal luminal cells (Wang et al., 2013), as well as by the Ck4-CreERT2 driver, which is specific for LumP cells (Guo et al., 2020).