Particularly, renal interstitial fibrosis is the prominent biological event of DN, and the renal tubular epithelial-to-mesenchymal transition (EMT), characterized by the increased expressions of the mesenchymal markers, vimentin, α-smooth muscle actin (α-SMA), and the decreased expression of the epithelial marker E-cadherin in tubular epithelia cell, is a relatively complex pathological mechanism on the DN. This evidence concerns the gene CDH1 and liver dysplastic nodule.