Moreover, HIF1α, which is regulated in a mtCa2+/mtROS-dependent manner in response to NCLX loss in CRC, also contributes to mitophagy, by upregulating the pro-mitophagy proteins BNIP3 and NIX (Bellot et al., 2009; Chourasia et al., 2015; Zhang et al., 2008; Zhang and Ney, 2009). The gene discussed is SLC8B1; the disease is colorectal carcinoma.