INS and Hypoglycemia: Closed-loop insulin delivery systems reduce the risk of hypoglycemia, but will not completely prevent it.2 When glucose levels approach hypoglycemia, closed-loop systems will often not have delivered any insulin for some time prior to this; therefore, sometimes less rapid-acting carbohydrate (eg, 4 g) can be used to prevent hypoglycemia or treat mild hypoglycemia (Level 1: glucose 3.0-3.9 mmol/L).