GRDim mice, which express a point‐mutant GR protein that forms less efficient GR homodimers and DNA interaction, were previously found to be extremely sensitive for TNF‐induced SIRS (Reichardt et al, 1998; Van Bogaert et al, 2011; Vandevyver et al, 2012; Ballegeer et al, 2018). The gene discussed is TNF; the disease is systemic inflammatory response syndrome.