Glucocorticoids (GCs; e.g., the synthetic dexamethasone (Dex)), which function by binding to the glucocorticoid receptor (GR), confer protection against Crohn's diseases (Van Assche et al, 2010) and against TNF‐induced intestinal damage and lethal shock, when given prior to TNF. The gene discussed is TNF; the disease is Crohn disease.