MAPT and supranuclear palsy, progressive, 1: Characteristic neuropathological findings are intracellular aggregation of hyperphosphorylated tau protein with four microtubule binding repeat domains (4-repeat tau) in oligodendrocytes (coiled bodies), astrocytes (tufted astrocytes), and neurons (neurofibrillary tangles).1–3 A definite diagnosis of PSP can only be established currently by postmortem neuropathological brain examination.1,4