Mothers against decapentaplegic homolog 2 (Smad2), a downstream gene of the transforming growth factor beta (TGF‐β) signalling pathway, is associated with increased TGF‐β levels and poor prognosis, which leads to increased survival of metastatic cells and organ colonization in advanced CRC.70 The gene discussed is TGFB1; the disease is colorectal carcinoma.