SMPDL3b expression has also been found in pancreatic zymogen granules [91], in plasma protein-depleted cerebrospinal fluid [92], in saliva exosomes [93], in human milk [94], liver [95], and hepatocellular carcinoma [96], suggesting a diverse function of SMPDL3b in different tissues and organs. This evidence concerns the gene SMPDL3B and hepatocellular carcinoma.