Additionally, treatment with berberine improved renal injury in STZ-induced diabetic rats via downregulation of S1PR2 [105] and the use of the S1PR2 specific antagonist LTE-013 showed improved insulin resistance in human and rat hepatocytes [106], suggesting the possibility that S1PR2 inhibition may prove useful for the treatment of diabetes and its related complications. This evidence concerns the gene S1PR2 and diabetes mellitus.