This will be due to multiple mechanisms that include insufficient T cell trafficking to the tumor, CAR T cell suppression due to soluble mediators (like adenosine, TGFβ, and prostaglandin E2), upregulation of checkpoint inhibitors (like PD1) on the CARs, and CAR suppression due to intrinsic inhibitory T cell programs [50]. This evidence concerns the gene TGFB1 and neoplasm.