In the United States, brentuximab vedotin is currently approved for previously untreated stage III/IV classical Hodgkin Lymphoma (HL), consolidation therapy after autologous hematopoietic stem cell transplantation for classical HL and relapsed primary cutaneous ALCL or CD30 expressing mycosis fungoides [56]. Here, TNFRSF8 is linked to anaplastic large cell lymphoma.