In a syngeneic orthotopic murine model of glioma, CD4+ depletion completely nullified tumor lysate vaccine/Fc-OX40L treatment efficacy, and the survival effects were found to be driven in part by antibody-dependent cell mediated cytotoxicity (ADCC) and natural killer T cell (NKT) populations [21]. Here, TNFSF4 is linked to central nervous system cancer.