These findings are in line with a study on 112 cancers of ampullary origin, demonstrating that the mutational spectrum in I-type tumors resembles that of colorectal cancer, and the mutational spectrum in PB-type tumors resembles that of pancreatic cancer.12 In the current study, mutations in APC but not in CDKN2A were found to be prognostic. Here, APC is linked to cancer.