AEs of special interest included arthralgia (19 of 62 patients; 31%), cutaneous SCC (including keratoacanthoma; 16 of 62 patients; 26%), fatigue (34 of 62 patients; 55%), prolonged QT interval (11 of 62 patients; 18%), and liver injury (increased ALT, AST, blood alkaline phosphatase, bilirubin, and gamma-glutamyltransferase, as well as the hepatobiliary disorders hyperbilirubinemia, hepatocellular injury, and cholestatic jaundice; 16 of 62 patients; 26%). The gene discussed is GPT; the disease is keratoacanthoma.