Receptor tyrosine kinase activation in GI stromal tumor (GIST) is an emblematic example in which molecular characterization provides diagnostic, prognostic, and predictive information and enables improved outcomes.155 GISTs are intrinsically resistant to radiation and chemotherapy, being historically associated with poor prognosis because of the lack of effective treatment.156 For illustration, before the 1990s, recurrence rates reached 50% after resection, and median OS for metastatic GIST was approximately 9 months.157. The gene discussed is NTRK1; the disease is gastrointestinal stromal tumor.