Previous studies indicate that miR-324-5p is involved in the processes of cancer progression, cell proliferation, cell apoptosis, and cell migration.18, 19, 20, 21, 22, 23, 24, 25, 26, 27 Herein, we linked the miR-324-5p-KLF3 regulatory process with the progression of pancreatic cancer via promoting proliferation and suppressing apoptosis. The gene discussed is KLF3; the disease is pancreatic neoplasm.