MTOR and diabetes mellitus: Strategies typically implemented in an attempt to ameliorate CRD post-LTx may include (1) reduction in CNI target levels; (2) addition or substitution of rapamycin, an mTOR-inhibitor; (3) discontinuation of proton pump-inhibitors (PPI); (4) optimization of hypertension and diabetes mellitus; and (5) avoidance of nephrotoxic medications, when clinically feasible.