KDR and hepatocellular carcinoma: In the last few years, a number of other tyrosine kinase inhibitors (TKIs) have been investigated, and lenvatinib (an inhibitor against the VEGFR1, VEGFR2, and VEGFR3 kinases) and cabozantinib (an inhibitor of the tyrosine kinases c-Met, VEGFR2, AXL, and RET) are now also approved as treatments for patients with metastatic HCC [2, 3].