Conversely, tetratricopeptide repeat (TPR) domain protein 39B (TTC39B, C9orf52) (T39), a high density lipoprotein (HDL) gene discovered in human genome wide association studies (GWAS) 44, 45, is associated with atherosclerosis and steatohepatitis as well as inflammation 46. The gene discussed is TTC39B; the disease is atherosclerosis.