In Wurmbach's dataset 20, CDCA2, CDCA3, CDCA4, CDCA5 and CDCA8 were up-regulated in hepatocellular carcinoma (HCC), with fold changes of 1.813, 3.214, 1.832, 2.422 and 1.693, respectively. This evidence concerns the gene CDCA4 and hepatocellular carcinoma.