Moreover, oncolytic adenovirus infection can result in the upregulation of pro-apoptosis proteins (e.g., BAX, BIM, and BIK) without resulting in the activation of caspases 42-45, whereas TRAIL is able to induce apoptosis via caspases along with the transmission of BAX and BIM 41, 46. This evidence concerns the gene BCL2L11 and adenoviridae infectious disease.