PTEN and nonpapillary renal cell carcinoma: The other factor was TRPV1 downregulation aberrantly correlated with PTEN (r = -0.206, P = 1.63e-06), a classic tumor suppressor, and VEGFA (r = -0.493, P = 0e+00), which is widely viewed as a promoting gene of ccRCC (Figure S5).