Previous studies have proved the several classical signaling mechanisms were involved in promoting ccRCC, such as VHL/HIF1α 40, PI3K/Akt/mTOR 41, HGF/MET 42, MAPK 43, and Wnt/β-Catenin 44, etc. TRPV1 expression was discovered to be negatively correlated with expression of the key proteins in those pathways and positively correlated to cancer inhibiting genes, p53 and VHL. Here, PIK3CA is linked to cancer.