Using a univariate logistic model, we detected positive associations between type I EC risk and serum C-peptide, estrone, insulin, and androgen (including testosterone and androstenedione) levels, BMI, WHR, family history of cancer, nulliparous, irregular menstruation, diabetes, and hypertension (P < 0.001; Table 2). The gene discussed is INS; the disease is diabetes mellitus.