ALKBH5 expression significantly upregulates in endometrial cancer, and ALKBH5 demethylate the m6A modifications of IGF1R transcripts, and promotes IGF1R expression leading to the activation of the IGF signaling pathway, which consequently induces COL1A1 and MMP9 expression, subsequently increases the invasion and migration of endometrial cells. Here, IGF1R is linked to endometrial cancer.