To further confirm that our results extend beyond the HEC-1-A endometrial cancer cell line, we tested the effects of knockdown and overexpression of ALKBH5 in a second endometrial cancer cell line (RL95-2), as well as human endometrial stromal cells (T-HESCs), a normal non-transformed cell line, and found similar effects on the activity of endometrial cell (Figure 3), these results furtherly indicated that ALKBH5 could promote the activity of endometrial cell. The gene discussed is ALKBH5; the disease is endometrial cancer.