We serially monitored the antibody profile specific to RBD, S1, ECD and NP during the disease progression phase of COVID-19 patients (Fig 2 and S1 Fig). Overall, 24 (92.31%) out of 26 patients were seroconverted, whereas 2 patients (P22 and P23) showed a barely detectable level of both IgM and IgG response against four SARS-CoV-2 antigens during our observation period. The gene discussed is CD40LG; the disease is COVID-19.