The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is a central regulator of cellular growth, proliferation and survival.1 Dysregulation of PI3K/AKT/mTOR activity is frequently observed in human cancers.2 As part of the mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2), mTOR is a key intracellular point of convergence for several pathways, thus representing an important therapeutic target. The gene discussed is MTOR; the disease is cancer.