We further investigated the multifunctionality of peripheral CD8 + T cells in the patients with T2D Peripheral CD8 + T cells derived from subjects with age- and gender-matched normal glucose tolerance (NGT, n = 15) and patients with T2D (DM, n = 19) (online supplementary Table S1) were stimulated by PMA/ionomycin (PMA/ION) for 6 h and subjected to cytokine assay. The gene discussed is CD8A; the disease is type 2 diabetes mellitus.