found that overexpressing clusterin reduces renal fibrosis in a unilateral ureteral obstruction model16, and Rosenberg et al. found that ageing clusterin-deficient mice develop moderate to severe mesangial lesions and have deposits of immune complex in the mesangium, compared to relatively few or no glomerular lesions in age-matched wild-type controls17. This evidence concerns the gene CLU and Ureteral obstruction.