Alternatively, in ME180 cells, discernible increased expression of SOX2 messenger RNA (mRNA) was identified under hypoxic conditions26, which is consistent with the evidence that in prostate cancer cells, enhanced SOX2 expression and HIF-1α- or HIF-2α-related phenotypes depend on the duration of exposure to hypoxia27. The gene discussed is SOX2; the disease is Familial prostate cancer.