The incidence rate of thyroid cancer increased rapidly all over the world since the 1970s, until now it has become the most common endocrine malignancy.1 Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) signaling is highly selected in thyroid cancers, particularly in papillary thyroid cancers (PTCs). Here, WNK2 is linked to thyroid cancer.