Moreover, we established pre-B-ALL xenograft nonobese diabetic/severe combined immunodeficiency (NOD/SCID) model using primary MNCs from one BCR-ABL1− pre-B-ALL patient who overexpressed HDAC7 (Supplementary Fig. 1) for testing the antitumor activity of CC1007 in vivo. Here, HDAC7 is linked to severe combined immunodeficiency.