We also showed that the expression of Fcgr1a, Itgam, Ccl3, and Cxcl10, which are involved in the regulation of phagocytosis and immune modulation of monocytes, displayed inductive overexpression in a dose- and time-dependent manner after low dose of CC1007 treatment (Fig. 4d), suggesting that CC1007 could induce cross-lineage differentiation in BCR-ABL1− pre-B-ALL cells. This evidence concerns the gene ITGAM and acute lymphoblastic leukemia.