CYCS and acute lymphoblastic leukemia: In our study, a low dose of CC1007 (≤1.25 μM) did not significantly induce BCR-ABL1− pre-B-ALL cells apoptosis and did not influence the expression of apoptosis-regulating molecules, such as BCL-2, Bax, caspase-3 and -9, and cytochrome C, suggesting that the apoptosis pathway was not activated.