HDAC7 and acute lymphoblastic leukemia: The above-mentioned results were also proven by subcellular localization assay for HDAC7 and MEF2C distributions, where both nuclear and cytoplasmic HDAC7 protein were significantly inhibited when BCR-ABL1− pre-B-ALL cells were treated with low dose of CC1007 (Fig. 5d, e), but nuclear MEF2C protein level was unchanged, suggesting that the distribution of HDAC7 may be an important determinant for the differentiation of Nalm-6 cells along the monocytic lineage.