To confirm the involvement of PPARδ in regulating CPT1A, we showed that treating PT130 cells or Apc/Kras tumor organoids with PPARδ agonist GW501516 directly stimulated the expression of CPT1A and PPARGC1A (a known PPARδ target gene) (Fig. 5a, b). Here, PPARGC1A is linked to neoplasm.