Our analysis focused on progression of motor symptoms in manifest HD cases discovered three CpGs: cg26919387 near PEX14 (p = 9.3 × 10−9), cg12823408 near GRIK4 (p = 3.0 × 10−8), and cg21497164 in COX4I2 (p = 6.5 × 10−8). The gene discussed is COX4I2; the disease is Huntington disease.