Here, we utilized a combination of peptide prediction and in vitro peptide stimulation with overlapping peptides from the spike (S), nucleocapsid (N), and membrane (M) proteins to identify two SARS-CoV-2 epitopes restricted by HLA-A*02:01 (A2/S269 and A2/Orf1ab3183) in individuals with COVID-19. Here, HLA-A is linked to COVID-19.