In contrast, the A2/S269+CD8+ T cells from prepandemic and COVID-19 convalescent subjects were characterized by minimal levels of HLA-DR+CD38 and PD-1+CD71−, suggesting that, while the A2/S269+CD8+ set can be activated during the acute phase of the infection, it does not persist into short-term memory. This evidence concerns the gene CD8A and infection.