For example, the transcription factor GTF2I, located in the genomic region affected by copy number variation in Williams-Beuren (WBS) and 7Dup syndromes, is thought to contribute to the cognitive and social symptoms of both disorders [36]; GTF2I has been reported as a key contributor to the transcriptional dysregulation observed in the induced pluripotent stem cells (iPSC) derived from WBS and 7Dup patients [37]. This evidence concerns the gene GTF2I and Down syndrome.