Next, for confirmatory analyses in the CN group, we further investigated the associations between AD-CT and each of the abovementioned five measurements of stenosis that showed association in exploratory univariable analyses (p < 0.05), as well as the association between HVa and presence of any intracranial stenosis, after controlling for the effects of age, sex, and APOE4 carrier status (Table 4). This evidence concerns the gene APOE and Alzheimer disease.