F2 and blood coagulation disease: Although the patient had no clinical bleeding tendency, a blood test prior to surgery showed coagulopathy: platelet count (PLT) 117 × 109/L, prothrombin time–international normalized ratio (PT-INR) 1.78, activated partial thromboplastin time (APTT) 69.7 seconds, fibrinogen < 50 mg/dl, and D-dimer 1560 μg/ml.