MTHFR and male infertility: The N. Gupta and colleagues studied the Indian population [18], Wiener’s worked on the men’s idiopathic infertility in Russian population [19], Z. Ren and colleagues studied the Chinese population [20], and V. Rai and P. Kumar research [21] focused on the relationship between one type of MTHFR A1298C and male infertility.