In another 15 independent CRC patients with liver metastasis, we also observed a significantly lower expression of LOXL1 in CRC and CRC with liver metastasis tissues than in normal colorectal tissues (Fig. 1d), and the difference in IHC staining scores was statistically significant (P < 0.001) (Fig. 1e). Here, LOXL1 is linked to colorectal carcinoma.