Comparisons of the clinical characteristics and laboratory parameters between the CTS and without CTS groups revealed that the mean age, female rate, median duration of hemodialysis, ratio of shoulder pain, prevalence of HBV, HCV infection, median hs-CRP level, median β2-M concentration and ratio of patients with low serum prealbumin in the CTS group were significantly increased compared with the without CTS group (p < .05, .001). This evidence concerns the gene CRP and carpal tunnel syndrome.