Eight out of 28 proteins were also involved in the breast cancer pathway (hsa05224) and these proteins refer to EGFR and RAS signal transduction pathways, thus including proteins like EGFR, NRAS, PTEN, RPS6KB1, SP1, SOS2, FOS, and E2F2 transcription factor (Figure 7). The gene discussed is SOS2; the disease is breast carcinoma.