Eight out of 28 proteins were also involved in the breast cancer pathway (hsa05224) and these proteins refer to EGFR and RAS signal transduction pathways, thus including proteins like EGFR, NRAS, PTEN, RPS6KB1, SP1, SOS2, FOS, and E2F2 transcription factor (Figure 7). This evidence concerns the gene E2F2 and breast carcinoma.