PIK3CA and breast cancer: Within these pathways, the most targeted genes were genes belonging to the Wnt/B-catenin pathway, the MAPKs pathway, and the PI3K/Akt pathway such as MAPK1, AKT family, PIK3 family, RAS/RAF genes, CCND1, EGFR, PTEN, etc. The alteration of all of these genes is known to be responsible for the development of BC [81].