The same mice conversely are protected from LPS induced septic shock [44], rheumatoid arthritis [61,92], hemophilic arthropathy [93], lupus nephritis [64], post intestinal ischaemia reperfusion acute lung injury [94], renal injury from particulate matter [95] and inflammatory bowel disease [96], all of which are TNFα mediated with the exception of lupus nephritis which is TNFα and HB-EGF mediated [64]. The gene discussed is HBEGF; the disease is lupus nephritis.