Furthermore,oral squamous cell carcinoma patient samples have been shown to over-expressiRhom2, which was found to correlate with poor patient survival but no otherclinico-pathological variables [105].Moreover, iRhom2 expression was increased in cirrhotic liver samples [52], kidney tissue of Lupus nephritis patients [64], and colon samples from inflammatory boweldisease patients [96]. This evidence concerns the gene RHBDF2 and oral cavity squamous cell carcinoma.