Interestingly, our transcriptomic analysis of AML TILs showed that a set of these genes (namely, ATG3, BAX, CASP1, CASP2, CASP3, CASP6, CFLAR, and FAS), was upregulated compared to that in HD lymphocytes, thus suggesting that their expression could be partly causing miR-21 overexpression in these cells. This evidence concerns the gene CASP6 and acute myeloid leukemia.