Interestingly, some of the upregulated proapoptotic genes in miR-21-transduced T lymphocytes were also upregulated in AML T lymphocytes compared to HD cells, including BAX, CASP1, CASP3, FAS, CFLAR, and TNFRSF1A (Figure 1B). This evidence concerns the gene CASP3 and acute myeloid leukemia.