VEGFA and age-related macular degeneration: VEGF-A has been extensively studied in angiogenesis because it is essential for all stages of cardiovascular development and plays a major role in tumour angiogenesis and neovascularisation in eye pathologies such as Age-related Macular Degeneration (AMD) and Proliferative Diabetic Retinopathy (PDR) [74,77,78].