In addition to β-amyloid (Aβ) and tau pathobiology, cerebrovascular dysfunction and vascular pathology contribute to AD and increasing evidence strongly suggests that cerebrovascular dysfunction and vascular pathology is not merely a comorbidity but vascular damage and disfunction occurs either before [302] or in parallel of the accumulation of Aβ [302,303,304]. Here, MAPT is linked to Alzheimer disease.