THOP1 and early-onset autosomal dominant Alzheimer disease: IPA of the fetal thymus RNA seq data indicated that the first five primary canonical pathways influenced by maternal influenza infection were: (1) calcium signaling, (2) cellular effects of Sildenafil (Viagra), (3) tight junction signalling, (4) hepatic fibrosis/hepatic stellate cell activation and (5) neuroprotective role of Thimet Oligopeptidase 1 (THOP)1 in Alzheimer’s disease (Figure 4 and Supplementary Figure S1).