In AD patients showing IgE crossreactive to both the autoantigen Hom s4 and the grass allergen Phl p7, basophil degranulation could only be induced by the auto-antigen at concentrations in the μg/mL range, when compared to the allergen, which could induce degranulation in the pg/mL range [52]. This evidence concerns the gene IGHE and Alzheimer disease.