Human manganese superoxide dismutase (MnSOD, SOD2) and ribosomal P2 protein (RPLP2) share similarities with Aspergillus fumigatus and Malassezia sp. allergens (Asp f6 or Mala s11 and Asp f8, respectively), and elicit specific IgE responses in 42% and 8% of AD patients, respectively. This evidence concerns the gene IGHE and Alzheimer disease.