IGHE and multiple sclerosis: Evidence for a role of basophils in models of diseases associated with both AD and IgE autoreactivity [50] has already been described (i.e., in allergic rhinoconjunctivitis and allergic asthma [155,156], chronic spontaneous urticarial [157,158], rheumatoid arthritis [159], multiple sclerosis [160], and SLE [161]).