However, evidence of a high prevalence of autoreactive IgE, of their capacity to induce degranulation in vitro and in vivo, and of the accessibility to various sources of auto-antigens in the chronic lesions of AD patients, suggests that IgE autoreactivity is occurring in AD lesions, and that it could be important for the AD pathogenesis. The gene discussed is IGHE; the disease is Alzheimer disease.