In AD models, type 2 innate effector cells such as ILC2s, eosinophils, mast cells, and basophils have been shown to be pathogenic and responsible for the increased production of the type 2 cytokines IL-4 and IL-13, which induces epidermal hyperplasia [7,29,30,31,32,33]. The gene discussed is IL4; the disease is Alzheimer disease.