On the other hand, we and others have described that the Wnt/β-catenin signaling pathway is constitutively activated in a panel of STS cell lines and tumor-derived cells (liposarcomas, leiomyosarcomas, synovial sarcomas and fibrosarcomas), which confer them a highly proliferative and survival capacity, with CDC25A being a key target gene [11,13,14]. The gene discussed is CDC25A; the disease is liposarcoma.