APOE and Alzheimer disease: About 95% of AD cases are sporadic (SAD) and have a later onset (after 65 years of age): although SAD cases lack a Mendelian cause, variants of genes such as Apolipoprotein E (APOE) [64,65], and triggering receptors expressed on myeloid cells 2 (TREM2) [66] are known to increase the risk of developing SAD.