Moreover, an AD-specific epitope formed by two discontinuous portions of tau, 7EFE9 and 313VDLSKVTSKC322 and recognized by the MC1 antibody [198,202,203], represents an early aberrant conformation of tau present both in a soluble form of the protein and in paired helical filaments (PHF) assemblies [204]. The gene discussed is MAPT; the disease is Alzheimer disease.