MAPT and Alzheimer disease: Relevant to our discussion, the immune system is activated (early) in AD, and may contribute, by means of ineffective clearance of Aβ and tau by the microglia, to the diffusion of such pathology to neighboring or connected areas [77,78], and inflammation per se is a trigger to further production of Aβ and activation of kinases to hyper-phosphorylate tau [79], cascading more neuropathology.