In addition to focusing on crucial site-specific phosphorylation, it has been shown, by cryo-EM analysis in AD as well as in other tauopathies, that the most disease-specific change is a tridimensional folding of the tau filaments, which is a signature of the particular disease examined; these tau molecular conformers can in fact differentiate between AD, Pick’s disease and corticobasal degeneration (CBD) [198,199,200,201]. Here, MAPT is linked to Pick disease.