The study shows that (1) p-T217 and p-T181 rise in parallel to aggregated Aβ as early as 20 years before the development of neurofibrillary tangles, (2) p-T205 correlates with hypometabolism and atrophy closer to symptom onset, and (3) t-tau spikes when cognitive decline manifests. The gene discussed is MAPT; the disease is Mental deterioration.