TARDBP and Alzheimer disease: Finally, TAR DNA-binding protein 43 (TDP-43) pathology, more commonly found in cases of frontotemporal lobe degeneration (FTD), can be present in AD, in the amygdala, hippocampus and eventually in the neocortex and more diffusely [47,48], being not specific of AD, but underlying the vast array of cellular dysfunction present in this disease, which can affect RNA-related metabolism as well [49].