In AD, tau undergoes significant conformational change and abnormal phosphorylation, leading to the formation of inclusions throughout the brain, that start in the entorhinal cortex (EC) and, as the disease evolves, spread progressively throughout the brain, leading to synapse loss and neuronal death, which correlate well with the clinical onset and progression of symptoms [25,183,184]. This evidence concerns the gene MAPT and Alzheimer disease.